Although named after Queen Anne, this small square actually contains a statue of Queen Charlotte, wife of George III.
When George III became ill with a hereditary kidney disease, he stayed at the house of a doctor in Queen Square. The illness, causing bouts of insanity, resulted in the king's eldest son, later George IV, being made Prince Regent in 1811. George III never recovered and died in 1820.
Queen Square has retained some early-Georgian buildings on its west side but today is mostly dominated by the buildings of Great Ormond Street Hospital.